Diethylstilbestrol (D.E.S.) COMPOUND


DIETYLSTILBESTROL (D.E.S.) is used primarily for the treament of urinary incontinence in spayed female dogs.

*Tiny tablets and capsules of this product can only be dispensed in 180 day quantities due to compounding expiration dates. Chewables can only be dispensed in 30 day quantities. Please adjust your order accordingly.*

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Diethylstilbestrol (D.E.S.) Compound Basics

Diethylstilbestrol (D.E.S.) Compound is a synthetic estrogen. It treats enlarged prostate, estrogen responsive tumorsperianal gland adenomas, pregnancy prevention, and urinary incontinence in spayed females. This medication increases the responsiveness of the smooth muscle of the bladder neck, thus tightening the muscle and preventing urine from leaking. D.E.S. is used as an extra-label medication in veterinary medicine.

Diethylstilbestrol (D.E.S.) Compound requires a prescription from your veterinarian. It is available as a capsule, tiny tablet, or chewable.

Our pharmacists specially formulate all PetMart Pharmacy compounds to meet the needs of your pet. Please contact us if you need another form, strength, or flavor of this compound. All compounds ship within 1 day of preparation according to their specific temperature requirements.

Diethylstilbestrol (D.E.S.) Compound Directions

Use as directed by your veterinarian, and follow all instructions printed on the prescription label. Complete the entire prescription unless instructed otherwise by your veterinarian. Duration of administration depends on the condition being treated, the response to the medication, and development of any adverse effects. Allow your pet access to plenty of water throughout treatment.

Store at room temperature, protected from light and moisture.

Diethylstilbestrol (D.E.S.) Compound Warnings

Keep out of the reach of children and pets. Use in dogs only. Do not use in pets with a known allergy to D.E.S. Never use this medication in pregnant or lactating animals. Pregnant women, or women trying to become pregnant, should avoid contact with D.E.S. Do not use in animals with cancers that may be worsened by estrogens, such as breast cancer. Prolonged use of this medication may cause ovarian cancer. Excessive doses can cause a decrease in platelets, red blood cells, and white blood cells. Therefore, blood and platelet counts should be monitored on a regular basis throughout treatment. This medication can also increase the chances of uterine infections (pyometra) in unspayed females. Finally, if you notice any behavioral or physiological changes in your pet while administering this medication, contact your veterinarian immediately.

Adverse Reactions and Serious Side Effects

Adverse reactions and serious side effects are rare, however, they can occur. In the case of a more serious side effect, you should stop D.E.S. treatment and seek veterinary attention. Common signs of an adverse reaction or more serious side effect are facial swelling, breathing difficulties, pale mucous membranes, vaginal discharge, bleeding from the gastrointestinal or urinary tracts, uterine infections, or bone marrow depression.

If you have any additional questions regarding this product, please contact us at (877)220-6337. A member of our pharmacy staff will be happy to assist you!

Additional information


Capsule, Chewable, Tiny Tablet

Prescription Strength

0.2mg, 0.25mg, 0.4mg, 0.5mg, 0.6mg, 0.7mg, 1mg, 2mg, 5mg